Identification of repurposable cytoprotective drugs in vanishing white matter disease patient-derived cells

Identification of repurposable cytoprotective drugs in vanishing white matter disease patient-derived cells

Abstract Background Vanishing white matter disease (VWMD) is a rare disease caused by mutations of the guanine exchange factor eIF2B. VWMD typically presents with juvenile onset, and there are few treatments for the disease. Recent progress in the field has established mitochondrial dysfunction and...

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Bibliographic Details
Main Authors: Neville Ng, Mauricio Castro Cabral-da-Silva, Simon Maksour, Tracey Berg, Martin Engel, Dina M. Silva, Dzung Do-Ha, Jeremy S. Lum, Sonia Sanz Muñoz, Nadia Suarez-Bosche, Claire H. Stevens, Lezanne Ooi
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Translational Medicine Communications
Subjects:
Vanishing white matter disease
Leukodystrophy
Cell stress
Drug repurposing
Induced pluripotent stem cells
Astrocytes
Online Access:http://link.springer.com/article/10.1186/s41231-020-00071-0

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http://link.springer.com/article/10.1186/s41231-020-00071-0

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