Low level genome mistranslations deregulate the transcriptome and translatome and generate proteotoxic stress in yeast

Low level genome mistranslations deregulate the transcriptome and translatome and generate proteotoxic stress in yeast

<p>Abstract</p> <p>Background</p> <p>Organisms use highly accurate molecular processes to transcribe their genes and a variety of mRNA quality control and ribosome proofreading mechanisms to maintain intact the fidelity of genetic information flow. Despite this, low lev...

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Bibliographic Details
Main Authors: Paredes João A, Carreto Laura, Simões João, Bezerra Ana R, Gomes Ana C, Santamaria Rodrigo, Kapushesky Misha, Moura Gabriela R, Santos Manuel AS
Format: Article
Language:English
Published: BMC 2012-06-01
Series:BMC Biology
Subjects:
Yeast
mistranslation
tRNA
protein synthesis
mRNA profiling
stress
proteotoxic stress
protein misfolding
unfolded protein response
Online Access:http://www.biomedcentral.com/1741-7007/10/55

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http://www.biomedcentral.com/1741-7007/10/55

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