Beyond the Driver Mutation: Immunotherapies in Gastrointestinal Stromal Tumors

Beyond the Driver Mutation: Immunotherapies in Gastrointestinal Stromal Tumors

Gastrointestinal stromal tumors (GISTs) are a subtype of soft tissue sarcoma (STS), and have become a concept of oncogenic addiction and targeted therapies.The large majority of these tumors develop after a mutation in KIT or platelet derived growth factor receptor α (PDGFRα), resulting in uncontrol...

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Bibliographic Details
Main Authors: Matthieu Roulleaux Dugage, Robin Lewis Jones, Jonathan Trent, Stéphane Champiat, Sarah Dumont
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
GIST - gastro intestinal stromal tumor
immunotherapy
PD-L1
imatinib
IDO - indoleamine 2,3-dioxygenase
KIT
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.715727/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.715727/full

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