PolyADP-Ribosylation of NFATc3 and NF-κB Transcription Factors Modulate Macrophage Inflammatory Gene Expression in LPS-Induced Acute Lung Injury

PolyADP-Ribosylation of NFATc3 and NF-κB Transcription Factors Modulate Macrophage Inflammatory Gene Expression in LPS-Induced Acute Lung Injury

Pulmonary macrophages play a critical role in the recognition of pathogens, initiation of host defense via inflammation, clearance of pathogens from the airways, and resolution of inflammation. Recently, we have shown a pivotal role for the nuclear factor of activated T-cell cytoplasmic member 3 (NF...

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Bibliographic Details
Main Authors: Yunjuan Nie, Teja Srinivas Nirujogi, Ravi Ranjan, Brenda F. Reader, Sangwoon Chung, Megan N. Ballinger, Joshua A. Englert, John W. Christman, Manjula Karpurapu
Format: Article
Language:English
Published: Karger Publishers 2020-10-01
Series:Journal of Innate Immunity
Subjects:
macrophage
polyadp-ribose polymerase 1
nfatc3
acute lung injury
pulmonary edema
Online Access:https://www.karger.com/Article/FullText/510269

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https://www.karger.com/Article/FullText/510269

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