Bone Metastasis Phenotype and Growth Undergo Regulation by Micro-Environment Stimuli: Efficacy of Early Therapy with HGF or TGFβ1-Type I Receptor Blockade

Bone Metastasis Phenotype and Growth Undergo Regulation by Micro-Environment Stimuli: Efficacy of Early Therapy with HGF or TGFβ1-Type I Receptor Blockade

Hepatocyte growth factor (HGF) and transforming growth factor β1 (TGFβ1) are biological stimuli of the micro-environment which affect bone metastasis phenotype through transcription factors, but their influence on the growth is scarcely known. In a xenograft model prepared with 183...

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Bibliographic Details
Main Authors: Paola Bendinelli, Paola Maroni, Valentina Dall’Olio, Emanuela Matteucci, Maria Alfonsina Desiderio
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:International Journal of Molecular Sciences
Subjects:
mesenchymal epithelial transition
epithelial mesenchymal transition
hepatocyte growth factor, HGF
transforming growth factor β1, TGFβ1
Twist
Snail
HAI-1
Online Access:https://www.mdpi.com/1422-0067/20/10/2520

Internet

https://www.mdpi.com/1422-0067/20/10/2520

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