Calmodulin shuttling mediates cytonuclear signaling to trigger experience-dependent transcription and memory

Calmodulin shuttling mediates cytonuclear signaling to trigger experience-dependent transcription and memory

Activity-dependent gene expression is thought to involve translocation of Ca2+/calmodulin (CaM) to the nucleus. Here, the authors examine a translocation-deficient mutant of γCaMKII, a Ca2+/CaM shuttle protein, to show that translocation of Ca2+/CaM is required for memory and synaptic plasticity.

Bibliographic Details
Main Authors: Samuel M. Cohen, Benjamin Suutari, Xingzhi He, Yang Wang, Sandrine Sanchez, Natasha N. Tirko, Nataniel J. Mandelberg, Caitlin Mullins, Guangjun Zhou, Shuqi Wang, Ilona Kats, Alejandro Salah, Richard W. Tsien, Huan Ma
Format: Article
Language:English
Published: Nature Publishing Group 2018-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04705-8

Internet

https://doi.org/10.1038/s41467-018-04705-8

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