The α6 GABA<sub>A</sub> Receptor Positive Allosteric Modulator DK-I-56-1 Reduces Tic-Related Behaviors in Mouse Models of Tourette Syndrome

The α6 GABA<sub>A</sub> Receptor Positive Allosteric Modulator DK-I-56-1 Reduces Tic-Related Behaviors in Mouse Models of Tourette Syndrome

Tourette syndrome (TS) is a disabling neurodevelopmental disorder characterized by multiple, recurrent tics. The pharmacological treatment of TS is currently based on dopaminergic antagonists; however, these drugs are associated with extrapyramidal symptoms and other serious adverse events. Recent e...

Full description

Bibliographic Details
Main Authors: Roberto Cadeddu, Daniel E. Knutson, Laura J. Mosher, Stefanos Loizou, Karen Odeh, Janet L. Fisher, James M. Cook, Marco Bortolato
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Biomolecules
Subjects:
DK-I-56-1
Tourette syndrome
tics
spontaneous eyeblinks
GABA<sub>A</sub> receptor
Online Access:https://www.mdpi.com/2218-273X/11/2/175

Internet

https://www.mdpi.com/2218-273X/11/2/175

Similar Items