Salsalate and Adiponectin Improve Palmitate-Induced Insulin Resistance via Inhibition of Selenoprotein P through the AMPK-FOXO1α Pathway.

Salsalate and Adiponectin Improve Palmitate-Induced Insulin Resistance via Inhibition of Selenoprotein P through the AMPK-FOXO1α Pathway.

Selenoprotein P (SeP) was recently identified as a hepatokine that induces insulin resistance (IR) in rodents and humans. Recent clinical trials have shown that salsalate, a prodrug of salicylate, significantly lowers blood glucose levels and increases adiponectin concentrations. We examined the eff...

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Bibliographic Details
Main Authors: Tae Woo Jung, Hae Yoon Choi, So Young Lee, Ho Cheol Hong, Sae Jeong Yang, Hye Jin Yoo, Byung-Soo Youn, Sei Hyun Baik, Kyung Mook Choi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0066529

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https://doi.org/10.1371/journal.pone.0066529

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