Ovotoxic effects of galactose involve attenuation of follicle-stimulating hormone bioactivity and up-regulation of granulosa cell p53 expression.

Clinical evidence suggests an association between galactosaemia and premature ovarian insufficiency (POI); however, the mechanism still remains unresolved. Experimental galactose toxicity in rats produces an array of ovarian dysfunction including ovarian development with deficient follicular reserve...

Full description

Bibliographic Details
Main Authors: Sayani Banerjee, Pratip Chakraborty, Piyali Saha, Soma Aditya Bandyopadhyay, Sutapa Banerjee, Syed N Kabir
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3271100?pdf=render