MAW point mutation impairs H. Seropedicae RecA ATP hydrolysis and DNA repair without inducing large conformational changes in its structure.

MAW point mutation impairs H. Seropedicae RecA ATP hydrolysis and DNA repair without inducing large conformational changes in its structure.

RecA is a multifunctional protein that plays a central role in DNA repair in bacteria. The structural Make ATP Work motif (MAW) is proposed to control the ATPase activity of RecA. In the present work, we report the biochemical activity and structural effects of the L53Q mutation at the MAW motif of...

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Bibliographic Details
Main Authors: Wellington C Leite, Renato F Penteado, Fernando Gomes, Jorge Iulek, Rafael M Etto, Sérgio C Saab, Maria B R Steffens, Carolina W Galvão
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0214601

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https://doi.org/10.1371/journal.pone.0214601

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