Intermittent induction of HIF-1α produces lasting effects on malignant progression independent of its continued expression.

Intermittent induction of HIF-1α produces lasting effects on malignant progression independent of its continued expression.

Dysregulation of hypoxia-inducible transcription factors HIF-1α and HIF-2α correlates with poor prognosis in human cancers; yet, divergent and sometimes opposing activities of these factors in cancer biology have been observed. Adding to this complexity is that HIF-1α apparently possesses tumor-supp...

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Bibliographic Details
Main Authors: Hyunsung Choi, David L Gillespie, Shauna Berg, Christopher Rice, Sandrine Couldwell, Jie Gu, Howard Colman, Randy L Jensen, L Eric Huang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0125125

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https://doi.org/10.1371/journal.pone.0125125

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