Protein polarization driven by nucleoid exclusion of DnaK(HSP70)–substrate complexes

Many bacterial proteins exhibit spatially defined localization important for function. Here the authors show that the polar localization of Shigella IpaC type III secretion substrate is mediated by its interaction with the DnaK chaperone and occlusion by the bacterial nucleoid.

Bibliographic Details
Main Authors: Clémence Collet, Jenny-Lee Thomassin, Olivera Francetic, Pierre Genevaux, Guy Tran Van Nhieu
Format: Article
Language:English
Published: Nature Publishing Group 2018-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04414-2