AXL receptor tyrosine kinase as a promising anti-cancer approach: functions, molecular mechanisms and clinical applications

AXL receptor tyrosine kinase as a promising anti-cancer approach: functions, molecular mechanisms and clinical applications

Abstract Molecular targeted therapy for cancer has been a research hotspot for decades. AXL is a member of the TAM family with the high-affinity ligand growth arrest-specific protein 6 (GAS6). The Gas6/AXL signalling pathway is associated with tumour cell growth, metastasis, invasion, epithelial-mes...

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Bibliographic Details
Main Authors: Chenjing Zhu, Yuquan Wei, Xiawei Wei
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Molecular Cancer
Subjects:
AXL
Receptor tyrosine kinase
Signaling pathway
Inhibitor
Cancer
Online Access:http://link.springer.com/article/10.1186/s12943-019-1090-3

Internet

http://link.springer.com/article/10.1186/s12943-019-1090-3

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