Advances in Models of Fibrous Dysplasia/McCune-Albright Syndrome

Advances in Models of Fibrous Dysplasia/McCune-Albright Syndrome

The Gs G-protein coupled receptor pathway is a critical regulator of normal bone formation and function. The Gs pathway increases intracellular cAMP levels by ultimately acting on adenylate cyclase. McCune-Albright Syndrome (MAS) and fibrous dysplasia (FD) of the bone are two proto-typical condition...

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Bibliographic Details
Main Authors: Hsuan Lung, Edward C. Hsiao, Kelly L. Wentworth
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Endocrinology
Subjects:
GPCR (G protein-coupled receptors)
McCune-Albright syndrome (MAS)
fibrous dysplasia (FD)
GNAS (guanine nucleotide-binding protein/[alpha]-subunit
Gsα
cAMP
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00925/full

Internet

https://www.frontiersin.org/article/10.3389/fendo.2019.00925/full

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