The Androgen Receptor in Prostate Cancer: Effect of Structure, Ligands and Spliced Variants on Therapy

The Androgen Receptor in Prostate Cancer: Effect of Structure, Ligands and Spliced Variants on Therapy

The androgen receptor (AR) plays a predominant role in prostate cancer (PCa) pathology. It consists of an N-terminal domain (NTD), a DNA-binding domain (DBD), a hinge region (HR), and a ligand-binding domain (LBD) that binds androgens, including testosterone (T) and dihydrotestosterone (DHT). Ligand...

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Bibliographic Details
Main Authors: Elisabeth A. Messner, Thomas M. Steele, Maria Malvina Tsamouri, Nazila Hejazi, Allen C. Gao, Maria Mudryj, Paramita M. Ghosh
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Biomedicines
Subjects:
castration-resistant prostate cancer
androgen receptor
N-terminal domain
DNA-binding domain
Ligand-binding domain
alternatively spliced variants
Online Access:https://www.mdpi.com/2227-9059/8/10/422

Internet

https://www.mdpi.com/2227-9059/8/10/422

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