Brozopine Inhibits 15-LOX-2 Metabolism Pathway After Transient Focal Cerebral Ischemia in Rats and OGD/R-Induced Hypoxia Injury in PC12 Cells

Brozopine Inhibits 15-LOX-2 Metabolism Pathway After Transient Focal Cerebral Ischemia in Rats and OGD/R-Induced Hypoxia Injury in PC12 Cells

The goal of this study was to elucidate the mechanisms of protection of Sodium (±)-5-bromo-2-(α-hydroxypentyl) benzoate (trade name: Brozopine, BZP) against cerebral ischemia in vivo and in vitro. To explore the protective effect of BZP on focal cerebral ischemia-reperfusion injury, we evaluated the...

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Bibliographic Details
Main Authors: Yuan Gao, Xinyu Cao, Xiaojiao Zhang, Yangjun Wang, He Huang, Yonggang Meng, Junbiao Chang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Pharmacology
Subjects:
brozopine
middle cerebral artery occlusion
15-HETE
PC12 cells
OGD/R
inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00099/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00099/full

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