Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response

Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response

The role of Endonuclease G in autophagy remains unclear. Here the authors report that ENDOG is released from mitochondria during starvation and promotes autophagy by suppressing mTOR signaling and activating DNA damage response.

Bibliographic Details
Main Authors: Wenjun Wang, Jianshuang Li, Junyang Tan, Miaomiao Wang, Jing Yang, Zhi-Min Zhang, Chuanzhou Li, Alexei G. Basnakian, Hong-Wen Tang, Norbert Perrimon, Qinghua Zhou
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-20780-2

Internet

https://doi.org/10.1038/s41467-020-20780-2

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