Chronic lymphocytic leukemia B-cell-derived TNFα impairs bone marrow myelopoiesis

Chronic lymphocytic leukemia B-cell-derived TNFα impairs bone marrow myelopoiesis

Summary: TNFα is implicated in chronic lymphocytic leukemia (CLL) immunosuppression and disease progression. TNFα is constitutively produced by CLL B cells and is a negative regulator of bone marrow (BM) myelopoiesis. Here, we show that co-culture of CLL B cells with purified normal human hematopoie...

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Bibliographic Details
Main Authors: Bryce A. Manso, Jordan E. Krull, Kimberly A. Gwin, Petra K. Lothert, Baustin M. Welch, Anne J. Novak, Sameer A. Parikh, Neil E. Kay, Kay L. Medina
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:iScience
Subjects:
Molecular Biology
Immunology
Stem Cells Research
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220311913

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http://www.sciencedirect.com/science/article/pii/S2589004220311913

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