Caution in interpreting results from imputation analysis when linkage disequilibrium extends over a large distance: a case study on venous thrombosis.

Caution in interpreting results from imputation analysis when linkage disequilibrium extends over a large distance: a case study on venous thrombosis.

By applying an imputation strategy based on the 1000 Genomes project to two genome-wide association studies (GWAS), we detected a susceptibility locus for venous thrombosis on chromosome 11p11.2 that was missed by previous GWAS analyses that had been conducted on the same datasets. A comprehensive l...

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Bibliographic Details
Main Authors: Marine Germain, Noémie Saut, Tiphaine Oudot-Mellakh, Luc Letenneur, Anne-Marie Dupuy, Marion Bertrand, Marie-Christine Alessi, Jean-Charles Lambert, Diana Zelenika, Joseph Emmerich, Laurence Tiret, Francois Cambien, Mark Lathrop, Philippe Amouyel, Pierre-Emmanuel Morange, David-Alexandre Trégouët
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3366937?pdf=render

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http://europepmc.org/articles/PMC3366937?pdf=render

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