Calorie Restriction-Induced Increase in Skeletal Muscle Insulin Sensitivity Is Not Prevented by Overexpression of the p55α Subunit of Phosphoinositide 3-Kinase

Calorie Restriction-Induced Increase in Skeletal Muscle Insulin Sensitivity Is Not Prevented by Overexpression of the p55α Subunit of Phosphoinositide 3-Kinase

Introduction: The Phosphoinositide 3-kinase (PI3K) signaling pathway plays an important role in skeletal muscle insulin-stimulated glucose uptake. While whole-body and tissue specific knockout (KO) of individual or combinations of the regulatory subunits of PI3K (p85α, p55α, and p50α or p85β); incre...

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Bibliographic Details
Main Authors: Vitor F. Martins, Shahriar Tahvilian, Ji H. Kang, Kristoffer Svensson, Byron Hetrick, Wallace S. Chick, Simon Schenk, Carrie E. McCurdy
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Physiology
Subjects:
Cre-LoxP
2-deoxyglucose
glucose tolerance
Pik3r1
insulin sensitivity
calorie restriction
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.00789/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2018.00789/full

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