Reliability of Whole-Exome Sequencing for Assessing Intratumor Genetic Heterogeneity

Reliability of Whole-Exome Sequencing for Assessing Intratumor Genetic Heterogeneity

Summary: Multi-region sequencing is used to detect intratumor genetic heterogeneity (ITGH) in tumors. To assess whether genuine ITGH can be distinguished from sequencing artifacts, we performed whole-exome sequencing (WES) on three anatomically distinct regions of the same tumor with technical repli...

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Bibliographic Details
Main Authors: Weiwei Shi, Charlotte K.Y. Ng, Raymond S. Lim, Tingting Jiang, Sushant Kumar, Xiaotong Li, Vikram B. Wali, Salvatore Piscuoglio, Mark B. Gerstein, Anees B. Chagpar, Britta Weigelt, Lajos Pusztai, Jorge S. Reis-Filho, Christos Hatzis
Format: Article
Language:English
Published: Elsevier 2018-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718316358

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http://www.sciencedirect.com/science/article/pii/S2211124718316358

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