α,β-D-constrained nucleic acids are strong terminators of thermostable DNA polymerases in polymerase chain reaction.

α,β-D-constrained nucleic acids are strong terminators of thermostable DNA polymerases in polymerase chain reaction.

(S(C5'), R(P)) α,β-D- Constrained Nucleic Acids (CNA) are dinucleotide building blocks that can feature either B-type torsional angle values or non-canonical values, depending on their 5'C and P absolute stereochemistry. These CNA are modified neither on the nucleobase nor on the sugar str...

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Bibliographic Details
Main Authors: Olivier Martínez, Vincent Ecochard, Sabrina Mahéo, Grégori Gross, Pierre Bodin, Justin Teissié, Jean-Marc Escudier, Laurent Paquereau
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3185000?pdf=render

Internet

http://europepmc.org/articles/PMC3185000?pdf=render

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