Rheumatoid Arthritis-Associated Autoimmunity Due to Aggregatibacter actinomycetemcomitans and Its Resolution With Antibiotic Therapy

Rheumatoid Arthritis-Associated Autoimmunity Due to Aggregatibacter actinomycetemcomitans and Its Resolution With Antibiotic Therapy

Background:Aggregatibacter actinomycetemcomitans (Aa) is a Gram-negative coccobacillus recognized as a pathogen in periodontitis and infective endocarditis. By producing a toxin (leukotoxin A, LtxA) that triggers global hypercitrullination in neutrophils, Aa has been recently linked to rheumatoid ar...

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Bibliographic Details
Main Authors: Amarshi Mukherjee, Vanessa Jantsch, Rida Khan, Wolfgang Hartung, René Fischer, Jonathan Jantsch, Boris Ehrenstein, Maximilian F. Konig, Felipe Andrade
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
rheumatoid arthritis
ACPA
anti-CCP
Aggregatibacter actinomycetemcomitans
autoantibodies
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02352/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02352/full

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