A new Defective Helper RNA to produce recombinant Sindbis virus that infects neurons but does not propagate

A new Defective Helper RNA to produce recombinant Sindbis virus that infects neurons but does not propagate

Recombinant Sindbis viruses are important tools in neuroscience because they combine rapid and high transgene expression with a capacity to carry large transgenes. Currently, two packaging systems based on the DH(26S)5’SIN and the DH-BB(tRNA;TE12) Defective Helper (DH) RNAs are available for generat...

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Bibliographic Details
Main Authors: Justus M Kebschull, Pedro eGarcia da Silva, Anthony M Zador
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-05-01
Series:Frontiers in Neuroanatomy
Subjects:
Sindbis Virus
viral tracing
neurotropism
Defective Helper RNAs
propagation competence
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnana.2016.00056/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnana.2016.00056/full

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