TDP-43-Mediated Toxicity in HEK293T Cells: A Fast and Reproducible Protocol To Be Employed in the Search of New Therapeutic Options against Amyotrophic Lateral Sclerosis

TDP-43-Mediated Toxicity in HEK293T Cells: A Fast and Reproducible Protocol To Be Employed in the Search of New Therapeutic Options against Amyotrophic Lateral Sclerosis

Cytoplasmic TDP-43 aggregates are a hallmark of amyotrophic lateral sclerosis (ALS). Today, only two drugs are available for ALS treatment, and their modest effect prompts researchers to search for new therapeutic options. TDP-43 represents one of the most promising targets for therapeutic intervent...

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Bibliographic Details
Main Authors: Débora Lanznaster, Jérôme Bourgeais, Clement Bruno, Rudolf C. Hergesheimer, Rose-Anne Thepault, Patrick Vourc’h, Philippe Corcia, Christian R. Andres, Olivier Herault, Hélène Blasco
Format: Article
Language:English
Published: MDPI AG 2019-12-01
Series:Cells
Subjects:
als
tdp-43
aggregation
cellular death
apoptosis
metabolomics
Online Access:https://www.mdpi.com/2073-4409/9/1/68

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https://www.mdpi.com/2073-4409/9/1/68

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