Triptolide impairs genome integrity by directly blocking the enzymatic activity of DNA-PKcs in human cells

Triptolide impairs genome integrity by directly blocking the enzymatic activity of DNA-PKcs in human cells

Triptolide is a multi-functional natural small molecular compound extracted from a traditional Chinese medicinal herb. Triptolide and its derivatives exhibit cytotoxicity through inducing DNA damage, therefore increasing sensitivity to DNA-damage based chemotherapy or radiotherapy in different types...

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Bibliographic Details
Main Authors: Bailian Cai, Zhiyi Hu, Huanyin Tang, Zhangsen Hu, Zhiyong Mao, Binya Liu, Xiaojun Xu, Ying Jiang, Xiaoping Wan
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Triptolide
Genome integrity
DNA-PKcs
Non-homologous end joining
Online Access:http://www.sciencedirect.com/science/article/pii/S075333222030620X

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http://www.sciencedirect.com/science/article/pii/S075333222030620X

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