Complement-Dependent Modulation of Antitumor Immunity following Radiation Therapy

Complement is traditionally thought of as a proinflammatory effector mechanism of antitumor immunity. However, complement is also important for effective clearance of apoptotic cells, which can be an anti-inflammatory and tolerogenic process. We show that localized fractionated radiation therapy (RT...

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Bibliographic Details
Main Authors: Michelle Elvington, Melissa Scheiber, Xiaofeng Yang, Katherine Lyons, Dustin Jacqmin, Casey Wadsworth, David Marshall, Kenneth Vanek, Stephen Tomlinson
Format: Article
Language:English
Published: Elsevier 2014-08-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714005506