Genetic and functional interaction network analysis reveals global enrichment of regulatory T cell genes influencing basal cell carcinoma susceptibility

Genetic and functional interaction network analysis reveals global enrichment of regulatory T cell genes influencing basal cell carcinoma susceptibility

Abstract Background Basal cell carcinoma (BCC) of the skin is the most common form of human cancer, with more than 90% of tumours presenting with clear genetic activation of the Hedgehog pathway. However, polygenic risk factors affecting mechanisms such as DNA repair and cell cycle checkpoints or wh...

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Bibliographic Details
Main Authors: Christelle Adolphe, Angli Xue, Atefeh Taherian Fard, Laura A. Genovesi, Jian Yang, Brandon J. Wainwright
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Genome Medicine
Subjects:
BCC
GWAS
Cancer susceptibility
Immune surveillance
Protein interaction networks
Online Access:https://doi.org/10.1186/s13073-021-00827-9

Internet

https://doi.org/10.1186/s13073-021-00827-9

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