Plumbagin ameliorates liver fibrosis via a ROS-mediated NF-кB signaling pathway in vitro and in vivo

Plumbagin ameliorates liver fibrosis via a ROS-mediated NF-кB signaling pathway in vitro and in vivo

Aims: The purpose of this study was to investigate plumbagin (PL) on liver fibrosis in vitro and in vivo and to explore the underlying mechanisms. Methods: Carbon tetrachloride (CCl4) was used to establish a rat liver fibrosis model, primary hepatic stellate cells (HSCs) were isolated from the rat l...

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Bibliographic Details
Main Authors: Yongxin Chen, Chuan Zhao, Xuemei Liu, Guanyi Wu, Jing Zhong, Tiejian Zhao, Junxuan Li, Yuning Lin, Yanping Zhou, Yanfei Wei
Format: Article
Language:English
Published: Elsevier 2019-08-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Plumbagin
Liver fibrosis
ROS
NF-кB signaling pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332219311709

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http://www.sciencedirect.com/science/article/pii/S0753332219311709

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