MiRNA Targeted NP Genome of Live Attenuated Influenza Vaccines Provide Cross-Protection against a Lethal Influenza Virus Infection

MiRNA Targeted NP Genome of Live Attenuated Influenza Vaccines Provide Cross-Protection against a Lethal Influenza Virus Infection

The miRNA-based strategy has been used to develop live attenuated influenza vaccines. In this study, the nucleoprotein (NP) genome segment of the influenza virus was inserted by different perfect miRNA-192-5p target sites, and the virus was rescued by standard reverse genetics method, so as to verif...

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Bibliographic Details
Main Authors: Feixia Gao, Tianhan Yang, Xueying Liu, Feifei Xiong, Jian Luo, Yinglei Yi, Jiangfeng Fan, Ze Chen, Wen-Song Tan
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Vaccines
Subjects:
mirna-192-5p
influenza virus
np
live attenuated influenza vaccine
cross-protection
Online Access:https://www.mdpi.com/2076-393X/8/1/65

Internet

https://www.mdpi.com/2076-393X/8/1/65

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