Combined Use of Zoledronic Acid Augments Ursolic Acid-Induced Apoptosis in Human Osteosarcoma Cells through Enhanced Oxidative Stress and Autophagy

Combined Use of Zoledronic Acid Augments Ursolic Acid-Induced Apoptosis in Human Osteosarcoma Cells through Enhanced Oxidative Stress and Autophagy

Ursolic acid (UA), a naturally occurring pentacyclic triterpene acid found in many medicinal herbs and edible plants, triggers apoptosis in several tumor cell lines but not in human bone cancer cells. Most recently, we have demonstrated that UA exposure reduces the viability of human osteosarcoma MG...

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Bibliographic Details
Main Authors: Chia-Chieh Wu, Yi-Fu Huang, Chen-Pu Hsieh, Pin-Ju Chueh, Yao-Li Chen
Format: Article
Language:English
Published: MDPI AG 2016-11-01
Series:Molecules
Subjects:
zoledronic acid
ursolic acid
osteosarcoma
Online Access:http://www.mdpi.com/1420-3049/21/12/1640

Internet

http://www.mdpi.com/1420-3049/21/12/1640

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