Musashi-2, a novel oncoprotein promoting cervical cancer cell growth and invasion, is negatively regulated by p53-induced miR-143 and miR-107 activation

Musashi-2, a novel oncoprotein promoting cervical cancer cell growth and invasion, is negatively regulated by p53-induced miR-143 and miR-107 activation

Abstract Background Although previous studies have shown promise for targeting Musashi RNA-binding protein 2 (MSI-2) in diverse tumors, the role and mechanism of MSI-2 for cervical cancer (CC) progression and the regulation of MSI-2 expression remains unclear. Methods Using gene expression and bioin...

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Bibliographic Details
Main Authors: Peixin Dong, Ying Xiong, Sharon J. B. Hanley, Junming Yue, Hidemichi Watari
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Musashi-2
C-FOS
p53
microRNA-143
microRNA-107
Mithramycin a
Online Access:http://link.springer.com/article/10.1186/s13046-017-0617-y

Internet

http://link.springer.com/article/10.1186/s13046-017-0617-y

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