Diabetes mellitus is associated with elevated urinary pyrrole markers of γ-diketones known to cause axonal neuropathy

Introduction Progressive distal symmetrical axonal neuropathy, a complication of diabetes mellitus (DM), has an unknown cause. Normal physiological metabolism and diabetic dysmetabolism are associated with the generation of γ-diketones. γ-Diketones form pyrroles with protein amines, notably with axo...

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Bibliographic Details
Main Authors: Wenting Feng, Dafeng Lin, Xifei Yang, Peter Spencer
Format: Article
Language:English
Published: BMJ Publishing Group 2020-04-01
Series:BMJ Open Diabetes Research & Care
Online Access:https://drc.bmj.com/content/8/1/e001575.full