Flavonoid Compound Icariin Activates Hypoxia Inducible Factor-1α in Chondrocytes and Promotes Articular Cartilage Repair.

Flavonoid Compound Icariin Activates Hypoxia Inducible Factor-1α in Chondrocytes and Promotes Articular Cartilage Repair.

Articular cartilage has poor capability for repair following trauma or degenerative pathology due to avascular property, low cell density and migratory ability. Discovery of novel therapeutic approaches for articular cartilage repair remains a significant clinical need. Hypoxia is a hallmark for car...

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Bibliographic Details
Main Authors: Pengzhen Wang, Fengjie Zhang, Qiling He, Jianqi Wang, Hoi Ting Shiu, Yinglan Shu, Wing Pui Tsang, Shuang Liang, Kai Zhao, Chao Wan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4739592?pdf=render

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http://europepmc.org/articles/PMC4739592?pdf=render

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