Combined treatment of heterocyclic analogues and benznidazole upon Trypanosoma cruzi in vivo.

Chagas disease caused by Trypanosoma cruzi is an important cause of mortality and morbidity in Latin America but no vaccines or safe chemotherapeutic agents are available. Combined therapy is envisioned as an ideal approach since it may enhance efficacy by acting upon different cellular targets, may...

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Bibliographic Details
Main Authors: Denise da Gama Jaén Batista, Marcos Meuser Batista, Gabriel Melo de Oliveira, Constança Carvalho Britto, Ana Carolina Mondaine Rodrigues, Chad E Stephens, David W Boykin, Maria de Nazaré Correia Soeiro
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3144210?pdf=render