Aged Human Multipotent Mesenchymal Stromal Cells Can Be Rejuvenated by Neuron-Derived Neurotrophic Factor and Improve Heart Function After Injury

Aged Human Multipotent Mesenchymal Stromal Cells Can Be Rejuvenated by Neuron-Derived Neurotrophic Factor and Improve Heart Function After Injury

Reduced regenerative capacity of aged stem cells hampers the benefits of autologous cell therapy for cardiac regeneration. This study investigated whether neuron-derived neurotrophic factor (NDNF) could rejuvenate aged human bone marrow (hBM)- multipotent mesenchymal stromal cells (MSCs) and whether...

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Bibliographic Details
Main Authors: Hui-Fang Song, MD, PhD, Sheng He, MD, PhD, Shu-Hong Li, MD, MSc, Wen-Juan Yin, MD, MSc, Jun Wu, MD, MSc, Jian Guo, MD, PhD, Zheng-Bo Shao, MD, PhD, Xiao-Yan Zhai, MD, PhD, Hui Gong, MD, PhD, Li Lu, MD, PhD, Fang Wei, MD, PhD, Richard D. Weisel, MD, Jun Xie, MD, PhD, Ren-Ke Li, MD, PhD
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:JACC: Basic to Translational Science
Subjects:
aging
heart function
human stem cells
myocardial infarction
NDNF
rejuvenation
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X17302176

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http://www.sciencedirect.com/science/article/pii/S2452302X17302176

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