Seeded assembly in vitro does not replicate the structures of α‐synuclein filaments from multiple system atrophy

Seeded assembly in vitro does not replicate the structures of α‐synuclein filaments from multiple system atrophy

The propagation of conformational strains by templated seeding is central to the prion concept. Seeded assembly of α‐synuclein into filaments is believed to underlie the prion‐like spreading of protein inclusions in a number of human neurodegenerative diseases, including Parkinson's disease, de...

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Bibliographic Details
Main Authors: Sofia Lövestam, Manuel Schweighauser, Tomoyasu Matsubara, Shigeo Murayama, Taisuke Tomita, Takashi Ando, Kazuko Hasegawa, Mari Yoshida, Airi Tarutani, Masato Hasegawa, Michel Goedert, Sjors H. W. Scheres
Format: Article
Language:English
Published: Wiley 2021-04-01
Series:FEBS Open Bio
Subjects:
alpha‐synuclein
amyloid
cryo electron microscopy
multiple system atrophy
Online Access:https://doi.org/10.1002/2211-5463.13110

Internet

https://doi.org/10.1002/2211-5463.13110

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