Structure of the Rpn13-Rpn2 complex provides insights for Rpn13 and Uch37 as anticancer targets

Structure of the Rpn13-Rpn2 complex provides insights for Rpn13 and Uch37 as anticancer targets

In the proteasome, Rpn2 provides the docking site for substrate receptor Rpn13. Here the authors present the structure of human Rpn13 Pru domain bound to its binding site in Rpn2 and provide insights into the mode of action for Rpn13-targeting molecule RA190, which has anticancer properties.

Bibliographic Details
Main Authors: Xiuxiu Lu, Urszula Nowicka, Vinidhra Sridharan, Fen Liu, Leah Randles, David Hymel, Marzena Dyba, Sergey G. Tarasov, Nadya I. Tarasova, Xue Zhi Zhao, Jun Hamazaki, Shigeo Murata, Terrence R. Burke, Jr., Kylie J. Walters
Format: Article
Language:English
Published: Nature Publishing Group 2017-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms15540

Internet

https://doi.org/10.1038/ncomms15540

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