Mevalonate cascade regulation of airway mesenchymal cell autophagy and apoptosis: a dual role for p53.

Mevalonate cascade regulation of airway mesenchymal cell autophagy and apoptosis: a dual role for p53.

Statins inhibit the proximal steps of cholesterol biosynthesis, and are linked to health benefits in various conditions, including cancer and lung disease. We have previously investigated apoptotic pathways triggered by statins in airway mesenchymal cells, and identified reduced prenylation of small...

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Bibliographic Details
Main Authors: Saeid Ghavami, Mark M Mutawe, Pawan Sharma, Behzad Yeganeh, Karol D McNeill, Thomas Klonisch, Helmut Unruh, Hessam H Kashani, Dedmer Schaafsma, Marek Los, Andrew J Halayko
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3031577?pdf=render

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http://europepmc.org/articles/PMC3031577?pdf=render

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