Reciprocal relationship between APP positioning relative to the membrane and PS1 conformation
<p>Abstract</p> <p>Background</p> <p>Several familial Alzheimer disease (FAD) mutations within the transmembrane region of the amyloid precursor protein (APP) increase the Aβ<sub>42/40 </sub>ratio without increasing total Aβ production. In the present study,...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2011-02-01
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| Series: | Molecular Neurodegeneration |
| Online Access: | http://www.molecularneurodegeneration.com/content/6/1/15 |