Analysis of Stop Codons within Prokaryotic Protein-Coding Genes Suggests Frequent Readthrough Events

Analysis of Stop Codons within Prokaryotic Protein-Coding Genes Suggests Frequent Readthrough Events

Nonsense mutations turn a coding (sense) codon into an in-frame stop codon that is assumed to result in a truncated protein product. Thus, nonsense substitutions are the hallmark of pseudogenes and are used to identify them. Here we show that in-frame stop codons within bacterial protein-coding gene...

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Bibliographic Details
Main Authors: Frida Belinky, Ishan Ganguly, Eugenia Poliakov, Vyacheslav Yurchenko, Igor B. Rogozin
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
in-fame stop codon
expression
short-term evolution
population polymorphism
negative selection
Online Access:https://www.mdpi.com/1422-0067/22/4/1876

Internet

https://www.mdpi.com/1422-0067/22/4/1876

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