Establishment of HeLa cell mutants deficient in sphingolipid-related genes using TALENs.

Sphingolipids are essential components in eukaryotes and have various cellular functions. Recent developments in genome-editing technologies have facilitated gene disruption in various organisms and cell lines. We here show the disruption of various sphingolipid metabolic genes in human cervical car...

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Bibliographic Details
Main Authors: Toshiyuki Yamaji, Kentaro Hanada
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3912166?pdf=render