Thinking Outside the Box: Innate- and B Cell-Memory Responses as Novel Protective Mechanisms Against Tuberculosis
Tuberculosis (TB) is currently the deadliest infectious disease worldwide. Failure to create a highly effective vaccine has limited the control of the TB epidemic. Historically, the vaccine field has relied on the paradigm that IFN-γ-mediated CD4+ T cell memory responses are the principal correlate...
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doaj-3564f3867a334127b58b455365dc72ba2020-11-25T00:34:35ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-02-011110.3389/fimmu.2020.00226502454Thinking Outside the Box: Innate- and B Cell-Memory Responses as Novel Protective Mechanisms Against TuberculosisJosé Alberto Choreño-Parra0José Alberto Choreño-Parra1León Islas Weinstein2Edmond J. Yunis3Edmond J. Yunis4Joaquín Zúñiga5Joaquín Zúñiga6Rogelio Hernández-Pando7Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, MexicoLaboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, MexicoSection of Experimental Pathology, Department of Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, MexicoDepartment of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA, United StatesDepartment of Pathology, Harvard Medical School, Boston, MA, United StatesLaboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, MexicoTecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico City, MexicoSection of Experimental Pathology, Department of Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, MexicoTuberculosis (TB) is currently the deadliest infectious disease worldwide. Failure to create a highly effective vaccine has limited the control of the TB epidemic. Historically, the vaccine field has relied on the paradigm that IFN-γ-mediated CD4+ T cell memory responses are the principal correlate of protection in TB. Nonetheless, the demonstration that other cellular subsets offer protective memory responses against Mycobacterium tuberculosis (Mtb) is emerging. Among these are memory-like features of macrophages, myeloid cell precursors, natural killer (NK) cells, and innate lymphoid cells (ILCs). Additionally, the dynamics of B cell memory responses have been recently characterized at different stages of the clinical spectrum of Mtb infection, suggesting a role for B cells in human TB. A better understanding of the immune mechanisms underlying such responses is crucial to better comprehend protective immunity in TB. Furthermore, targeting immune compartments other than CD4+ T cells in TB vaccine strategies may benefit a significant proportion of patients co-infected with Mtb and the human immunodeficiency virus (HIV). Here, we summarize the memory responses of innate immune cells and B cells against Mtb and propose them as novel correlates of protection that could be harnessed in future vaccine development programs.https://www.frontiersin.org/article/10.3389/fimmu.2020.00226/fullMycobacterium tuberculosistrained immunityB-cellsmemory-like NK cellsILCs |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
José Alberto Choreño-Parra José Alberto Choreño-Parra León Islas Weinstein Edmond J. Yunis Edmond J. Yunis Joaquín Zúñiga Joaquín Zúñiga Rogelio Hernández-Pando |
spellingShingle |
José Alberto Choreño-Parra José Alberto Choreño-Parra León Islas Weinstein Edmond J. Yunis Edmond J. Yunis Joaquín Zúñiga Joaquín Zúñiga Rogelio Hernández-Pando Thinking Outside the Box: Innate- and B Cell-Memory Responses as Novel Protective Mechanisms Against Tuberculosis Frontiers in Immunology Mycobacterium tuberculosis trained immunity B-cells memory-like NK cells ILCs |
author_facet |
José Alberto Choreño-Parra José Alberto Choreño-Parra León Islas Weinstein Edmond J. Yunis Edmond J. Yunis Joaquín Zúñiga Joaquín Zúñiga Rogelio Hernández-Pando |
author_sort |
José Alberto Choreño-Parra |
title |
Thinking Outside the Box: Innate- and B Cell-Memory Responses as Novel Protective Mechanisms Against Tuberculosis |
title_short |
Thinking Outside the Box: Innate- and B Cell-Memory Responses as Novel Protective Mechanisms Against Tuberculosis |
title_full |
Thinking Outside the Box: Innate- and B Cell-Memory Responses as Novel Protective Mechanisms Against Tuberculosis |
title_fullStr |
Thinking Outside the Box: Innate- and B Cell-Memory Responses as Novel Protective Mechanisms Against Tuberculosis |
title_full_unstemmed |
Thinking Outside the Box: Innate- and B Cell-Memory Responses as Novel Protective Mechanisms Against Tuberculosis |
title_sort |
thinking outside the box: innate- and b cell-memory responses as novel protective mechanisms against tuberculosis |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2020-02-01 |
description |
Tuberculosis (TB) is currently the deadliest infectious disease worldwide. Failure to create a highly effective vaccine has limited the control of the TB epidemic. Historically, the vaccine field has relied on the paradigm that IFN-γ-mediated CD4+ T cell memory responses are the principal correlate of protection in TB. Nonetheless, the demonstration that other cellular subsets offer protective memory responses against Mycobacterium tuberculosis (Mtb) is emerging. Among these are memory-like features of macrophages, myeloid cell precursors, natural killer (NK) cells, and innate lymphoid cells (ILCs). Additionally, the dynamics of B cell memory responses have been recently characterized at different stages of the clinical spectrum of Mtb infection, suggesting a role for B cells in human TB. A better understanding of the immune mechanisms underlying such responses is crucial to better comprehend protective immunity in TB. Furthermore, targeting immune compartments other than CD4+ T cells in TB vaccine strategies may benefit a significant proportion of patients co-infected with Mtb and the human immunodeficiency virus (HIV). Here, we summarize the memory responses of innate immune cells and B cells against Mtb and propose them as novel correlates of protection that could be harnessed in future vaccine development programs. |
topic |
Mycobacterium tuberculosis trained immunity B-cells memory-like NK cells ILCs |
url |
https://www.frontiersin.org/article/10.3389/fimmu.2020.00226/full |
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