Early Response to the Plant Toxin Stenodactylin in Acute Myeloid Leukemia Cells Involves Inflammatory and Apoptotic Signaling

Early Response to the Plant Toxin Stenodactylin in Acute Myeloid Leukemia Cells Involves Inflammatory and Apoptotic Signaling

Stenodactylin, a highly toxic type 2 ribosome-inactivating protein purified from the caudex of Adenia stenodactyla Harms, is a potential anticancer drug candidate. Previous studies demonstrated that stenodactylin induces apoptosis and necroptosis in treated cells, involving the production of reactiv...

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Bibliographic Details
Main Authors: Daniele Mercatelli, Massimo Bortolotti, Vibeke Andresen, André Sulen, Letizia Polito, Bjørn Tore Gjertsen, Andrea Bolognesi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Pharmacology
Subjects:
acute myeloid leukemia
apoptosis
plant toxins
ribosome-inactivating protein
stenodactylin
toxic lectins
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00630/full

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https://www.frontiersin.org/article/10.3389/fphar.2020.00630/full

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