Repair of oxidative DNA base damage in the host genome influences the HIV integration site sequence preference.

Repair of oxidative DNA base damage in the host genome influences the HIV integration site sequence preference.

Host base excision repair (BER) proteins that repair oxidative damage enhance HIV infection. These proteins include the oxidative DNA damage glycosylases 8-oxo-guanine DNA glycosylase (OGG1) and mutY homolog (MYH) as well as DNA polymerase beta (Polβ). While deletion of oxidative BER genes leads to...

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Bibliographic Details
Main Authors: Geoffrey R Bennett, Ryan Peters, Xiao-hong Wang, Jeungphill Hanne, Robert W Sobol, Ralf Bundschuh, Richard Fishel, Kristine E Yoder
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4106905?pdf=render

Internet

http://europepmc.org/articles/PMC4106905?pdf=render

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