Repair of oxidative DNA base damage in the host genome influences the HIV integration site sequence preference.
Host base excision repair (BER) proteins that repair oxidative damage enhance HIV infection. These proteins include the oxidative DNA damage glycosylases 8-oxo-guanine DNA glycosylase (OGG1) and mutY homolog (MYH) as well as DNA polymerase beta (Polβ). While deletion of oxidative BER genes leads to...
Main Authors: | Geoffrey R Bennett, Ryan Peters, Xiao-hong Wang, Jeungphill Hanne, Robert W Sobol, Ralf Bundschuh, Richard Fishel, Kristine E Yoder |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4106905?pdf=render |
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