Acid Ceramidase Depletion Impairs Neuronal Survival and Induces Morphological Defects in Neurites Associated with Altered Gene Transcription and Sphingolipid Content

Acid Ceramidase Depletion Impairs Neuronal Survival and Induces Morphological Defects in Neurites Associated with Altered Gene Transcription and Sphingolipid Content

The <i>ASAH1</i> gene encodes acid ceramidase (AC), an enzyme that is implicated in the metabolism of ceramide (Cer). Mutations in the <i>ASAH1</i> gene cause two different disorders, Farber disease (FD), a rare lysosomal storage disorder, and a rare form of spinal muscular a...

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Bibliographic Details
Main Authors: Kalia Kyriakou, Carsten W. Lederer, Marina Kleanthous, Anthi Drousiotou, Anna Malekkou
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:International Journal of Molecular Sciences
Subjects:
acid ceramidase
sh-sy5y
neurites
ceramide
lipidomics
rho gtpases
lamp1
Online Access:https://www.mdpi.com/1422-0067/21/5/1607

Internet

https://www.mdpi.com/1422-0067/21/5/1607

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