Cross-Reactivity and Functionality of Approved Human Immune Checkpoint Blockers in Dogs

Cross-Reactivity and Functionality of Approved Human Immune Checkpoint Blockers in Dogs

Background: Rodent cancer models have limitations in predicting efficacy, tolerability and accompanying biomarkers of ICIs in humans. Companion dogs suffering from neoplastic diseases have gained attention as a highly relevant translational disease model. Despite successful reports of PD-1/PD-L1 blo...

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Bibliographic Details
Main Authors: Stanislav Pantelyushin, Elisabeth Ranninger, Diego Guerrera, Gregor Hutter, Caroline Maake, Enni Markkanen, Regula Bettschart-Wolfensberger, Carla Rohrer Bley, Heinz Läubli, Johannes vom Berg
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cancers
Subjects:
Translational cancer research
canine cancer
veterinary oncology
T cells
checkpoint blockade
PD-1/PD-L1
Online Access:https://www.mdpi.com/2072-6694/13/4/785

Internet

https://www.mdpi.com/2072-6694/13/4/785

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