LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation

LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation

The NLRP3 inflammasome is a multi-molecular protein complex that converts inactive cytokine precursors into active forms of IL-1β and IL-18. The NLRP3 inflammasome is frequently associated with the damaging inflammation of non-communicable disease states and is considered an attractive therapeutic t...

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Bibliographic Details
Main Authors: Jack P Green, Tessa Swanton, Lucy V Morris, Lina Y El-Sharkawy, James Cook, Shi Yu, James Beswick, Antony D Adamson, Neil E Humphreys, Richard Bryce, Sally Freeman, Catherine Lawrence, David Brough
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-11-01
Series:eLife
Subjects:
Inflammation
NLRP3 inflammasome
interleukin-1β
chloride
VRAC
RVD
Online Access:https://elifesciences.org/articles/59704

Internet

https://elifesciences.org/articles/59704

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