Cannabinoid Receptor 2 Modulates Maturation of Dendritic Cells and Their Capacity to Induce Hapten-Induced Contact Hypersensitivity

Cannabinoid Receptor 2 Modulates Maturation of Dendritic Cells and Their Capacity to Induce Hapten-Induced Contact Hypersensitivity

Contact hypersensitivity (CHS) is an established animal model for allergic contact dermatitis. Dendritic cells (DCs) play an important role in the sensitization phase of CHS by initiating T cell responses to topically applied haptens. The cannabinoid receptors 1 (CB1) and 2 (CB2) modulate DC functio...

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Bibliographic Details
Main Authors: Evelyn Gaffal, Andrea M. Kemter, Stefanie Scheu, Rafael Leite Dantas, Jens Vogt, Bernhard Baune, Thomas Tüting, Andreas Zimmer, Judith Alferink
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:International Journal of Molecular Sciences
Subjects:
allergic contact dermatitis
dendritic cells
skin inflammation
cb1
cb2
cannabinoid receptors
hapten 2,4-dinitro-1-fluorobenzene
mhc
migration
ccl19
cxcl12
Online Access:https://www.mdpi.com/1422-0067/21/2/475

Internet

https://www.mdpi.com/1422-0067/21/2/475

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